UPDATE 4.20PM: Police have confirmed the male driver of the vehicle involved in the crash on Tableland Rd has also died at the scene.
His partner was confirmed dead earlier on Monday.
UPDATE 1PM: Miriam Vale police officer in charge sergeant Owen Harms has confirmed the death of an elderly female passenger in Monday morning's crash on Tableland Rd in Taunton, about 4km south of Fingerboard Roadhouse.
An elderly male driver has been airlifted from the scene with critical injuries.
Sgt Harms confirmed the couple's sedan collided with a large tree while travelling north on the relatively straight stretch of road at about 11.30am.
Other motorists stopped and attempted to help the woman while calling for emergency services.
Sgt Harms said the accident was a tragic, timely reminder with Easter holidays on the horizon for motorists to drive with extra care.
"It's a timely reminder for people to take extra care on the roads," he said, while expressing the sadness felt by emergency services who attended the scene.
EARLIER: Traffic has been blocked in both directions on Tableland Rd after a suspected fatal crash at about 11am on Monday.
Gladstone Police can so far confirm a single vehicle carrying at least two people has collided with a tree, with a possible fatality arising from the crash.
The crash is believed to have occurred about 5km south of the Fingerboard Roadhouse, towards Bundaberg.
The condition of others involved is unknown at this stage, with updates to follow.
There are no detours available around the crash site.